FUPENTIXOL DIHYDROCHLORIDE
Fupentixol Dihydrochloride
CAS: 2413-38-9
Molecular Formula: C23H25F3N2OS.2ClH
FUPENTIXOL DIHYDROCHLORIDE - Names and Identifiers
FUPENTIXOL DIHYDROCHLORIDE - Physico-chemical Properties
| Molecular Formula | C23H25F3N2OS.2ClH |
| Molar Mass | 507.44 |
| Melting Point | 237-239 °C(Solv: ethanol (64-17-5); methanol (67-56-1)) |
| Boling Point | 554.7°C at 760 mmHg |
| Flash Point | 289.3°C |
| Water Solubility | soluble |
| Solubility | H2O: soluble |
| Vapor Presure | 3.87E-13mmHg at 25°C |
| Appearance | solid |
| Color | white or off-white |
| Storage Condition | Sealed in dry,2-8°C |
FUPENTIXOL DIHYDROCHLORIDE - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | 36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | TL9900000 |
| Toxicity | LD50 oral in rat: 791mg/kg |
FUPENTIXOL DIHYDROCHLORIDE - Reference Information
| atypical antipsychotic | flupentixol hydrochloride is the hydrochloride form of an atypical antipsychotic flupentixol, which is a thioanthracene derivative and has a strong blocking effect on dopamine receptors. in addition to blocking D1 and D2 receptors, flupentixol hydrochloride can also inhibit D2 self-receptors and increase DA concentration between synapses. No sedative effect. The antipsychotic effect is 4~8 times stronger than that of Terden. In addition, there are antidepressant and anti-anxiety effects. It can be used clinically for acute and chronic schizophrenia, and its decanoate is a long-acting agent. It is suitable for negative symptoms of schizophrenia such as apathy and withdrawal, and has certain curative effect on anxiety and lack of initial motivation. Its long-acting decanoate preparations are often used in the maintenance treatment of patients with chronic schizophrenia. Flupentixol, also known as difluothioxane hydrochloride, rehabilitation, trifluothioxane, hydroxypithianthracene, is a kind of thioanthracene atypical antipsychotic, white at room temperature Or light yellow powder, bitter taste. Soluble in water and ethanol. Its decanoate is yellow oil, light and smelly. The chemical structure of this type of drug is basically similar to that of phenothiazine antipsychotics, except that the 10th nitrogen atom on the phenothiazine ring is replaced by a carbon atom. The pharmacological effects are similar to phenothiazine antipsychotic derivative fluphenazine, and it has a better effect on symptoms such as apathy, contact passivity, decreased intention, and disobedience. In addition, this product has a strong antipsychotic effect, 4 to 8 times stronger than chlorprothione, and also has anti-anxiety and depression effects. The mechanism of action is to selectively block dopamine receptors in the central nervous system and produce antipsychotic effects. It can inhibit the reuptake of norepinephrine and serotonin by neurons in the brain, and produce antidepressant effects. The main drugs in this category are chlorprothione (Telden), tivorthione and flupentione. |
| biological activity | Flupentixol (Flupenthixol) dihydrochloride is an antipsychotic diazepam drug, a powerful antagonist of D1 and D2 dopamine receptors, and an antagonist of α adrenergic receptors. |
Last Update：2024-04-09 02:00:07
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